Review: multiple daily doses of antidepressants are not more effective than single daily doses.

Data extraction Data were extracted on study characteristics, drug regimen, sample size, compliance, mean baseline rating on depression scales, and percentage change at end point. Treatment effects were calculated and weighted in a meta-analysis. 3 different weights were used for each treatment effect to reflect 3 different assumptions about the correlation between baseline and follow up depression scores (ñ=0.9 [worst case scenario], ñ=0.5, and ñ=0).